Human Nectin-4/PVRL4 protein (Recombinant) (C-hFc) (STJP020112)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human Nectin-4/PVRL4 Protein is produced by mammalian expression system. The target protein is expressed with sequence (Gly32-Ser349) of Human Nectin-4/PVRL4 (Accession #Q96NY8) fused with an Fc tag at the C-terminus.
General Information
| Short Description | Recombinant-Human Nectin-4/PVRL4-C-hFc protein was developed in hek293 cells using the region Gly32-Ser349. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.2 Mu m filtered solution of PBS, pH 7.4.Contact us for customized product form or formulation. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 0.1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | NECTIN4 |
| Gene ID | 81607 |
| Uniprot ID | NECT4_HUMAN |
| Immunogen | Recombinant Human Nectin-4/PVRL4 Protein is produced by mammalian expression system. The target protein is expressed with sequence (Gly32-Ser349) of Human Nectin-4/PVRL4 (Accession #Q96NY8) fused with an Fc tag at the C-terminus. |
| Immunogen Region | Gly32-Ser349 |
| Immunogen Sequence | GELETSDVVTVVLGQDAKLP CFYRGDSGEQVGQVAWARVD AGEGAQELALLHSKYGLHVS PAYEGRVEQPPPPRNPLDGS VLLRNAVQADEGEYECRVST FPAGSFQARLRLRVLVPPLP SLNPGPALEEGQGLTLAASC TAEGSPAPSVTWDTEVKGTT SSRSFKHSRSAAVTSEFHLV PSRSMNGQPLTCVVSHPGLL QDQRITHILHVSFLAEASVR GLEDQNLWHIGREGAMLKC |
Additional Info
| Tissue Specificity | Predominantly expressed in placenta. Not detected in normal breast epithelium but expressed in breast carcinoma. |
| Post Translational Modifications | The soluble form is produced by proteolytic cleavage at the cell surface (shedding), probably by ADAM17/TACE. |
| Function | Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells. (Microbial infection) Acts as a receptor for measles virus. |
| Protein Name | Nectin-4Ig Superfamily Receptor LnirNectin Cell Adhesion Molecule 4Poliovirus Receptor-Related Protein 4 Cleaved Into - Processed Poliovirus Receptor-Related Protein 4 |
| Database Links | Reactome: R-HSA-418990Reactome: R-HSA-420597 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell JunctionAdherens JunctionColocalizes With Afdn At Cadherin-Based Adherens JunctionsProcessed Poliovirus Receptor-Related Protein 4: SecretedThe Secreted Form Is Found In Breast Tumor Patients |
| Alternative Protein Names | Nectin-4 proteinIg Superfamily Receptor Lnir proteinNectin Cell Adhesion Molecule 4 proteinPoliovirus Receptor-Related Protein 4 Cleaved Into - Processed Poliovirus Receptor-Related Protein 4 proteinNECTIN4 proteinLNIR proteinPRR4 proteinPVRL4 protein |
Information sourced from Uniprot.org