Human NDUFS2 protein (Recombinant) (His-Tag) (STJP018563)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human NDUFS2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Denatured |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NDUFS2 |
| Gene ID | 4720 |
| Uniprot ID | NDUS2_HUMAN |
| Accession Number | NP_004541 |
| Immunogen | Human |
| Immunogen Region | 77-463aa |
| Immunogen Sequence |
Additional Info
| Post Translational Modifications | Dimethylation at Arg-118 by NDUFAF7 takes place after NDUFS2 assembles into the complex I, leading to stabilize the early intermediate complex. |
| Function | Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I. Essential for the assembly of complex I. Redox-sensitive, critical component of the oxygen-sensing pathway in the pulmonary vasculature which plays a key role in acute pulmonary oxygen-sensing and hypoxic pulmonary vasoconstriction. Plays an important role in carotid body sensing of hypoxia. Essential for glia-like neural stem and progenitor cell proliferation, differentiation and subsequent oligodendrocyte or neuronal maturation. |
| Protein Name | Nadh Dehydrogenase Ubiquinone Iron-Sulfur Protein 2 - MitochondrialComplex I-49kdCi-49kdNadh-Ubiquinone Oxidoreductase 49 Kda Subunit |
| Database Links | Reactome: R-HSA-611105Reactome: R-HSA-6799198 |
| Cellular Localisation | Mitochondrion Inner MembranePeripheral Membrane ProteinMatrix Side |
| Alternative Protein Names | Nadh Dehydrogenase Ubiquinone Iron-Sulfur Protein 2 - Mitochondrial proteinComplex I-49kd proteinCi-49kd proteinNadh-Ubiquinone Oxidoreductase 49 Kda Subunit proteinNDUFS2 protein |
Information sourced from Uniprot.org