Human NCEH1 protein (Recombinant) (His-Tag) (STJP018109)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human NCEH1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Denatured |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NCEH1 |
| Gene ID | 57552 |
| Uniprot ID | NCEH1_HUMAN |
| Accession Number | NP_001139750 |
| Immunogen | Human |
| Immunogen Region | 1-275aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Expressed in monocyte-derived macrophages. Up-regulated in invasive melanoma and breast carcinoma cell lines. |
| Post Translational Modifications | N-glycosylated. |
| Function | Hydrolyzes 2-acetyl monoalkylglycerol ether (1-O-alkyl-2-acetyl-sn-glycerol), the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for the hydrolysis of cholesterol esters (such as cholesteryl (9Z-octadecenoate)) in macrophages. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds. May contribute to cancer pathogenesis by promoting tumor cell migration. |
| Protein Name | Neutral Cholesterol Ester Hydrolase 1NcehAcetylalkylglycerol Acetylhydrolase2-Acetyl Mage HydrolaseArylacetamide Deacetylase-Like 1 |
| Database Links | Reactome: R-HSA-8964038 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinMicrosome |
| Alternative Protein Names | Neutral Cholesterol Ester Hydrolase 1 proteinNceh proteinAcetylalkylglycerol Acetylhydrolase protein2-Acetyl Mage Hydrolase proteinArylacetamide Deacetylase-Like 1 proteinNCEH1 proteinAADACL1 proteinKIAA1363 protein |
Information sourced from Uniprot.org