Human NCE2/UBE2F protein (Recombinant) (His-Tag) (STJP017716)

Name: Human NCE2/UBE2F protein (Recombinant) (His-Tag) (STJP017716)
SKU: STJP017716
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostE.coli

ImmunogenHuman

STJP017716

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Short Description	Recombinant-Human NCE2/UBE2F-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications	SDS-PAGE
Host	E.coli
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Concentration	1 mg/mL
Formulation	Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 30% Glycerol, 1mM DTT, 200mM NaCl
Storage Instruction	For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.

Gene Symbol	UBE2F
Gene ID	140739
Uniprot ID	UBE2F_HUMAN
Accession Number	NP_542409
Immunogen	Human
Immunogen Region	1-185aa
Immunogen Sequence	MLTLAS KLKRDDGLKG SRTAATASDS TRRVSVRDKL LVKEVAELEA NLPCTCKVHF PDPNKLHCFQ LTVTPDEGYY QGGKFQFETE VPDAYNMVPP KVKCLTKIWH PNITETGEIC LSLLREHSID GTGWAPTRTL KDVVWGLNSL FTDLLNFDDP LNIEAAEHHL RDKEDFRNKV DDYIKRYAR

Tissue Specificity	Widely expressed (at protein level).
Post Translational Modifications	The acetylation of Met-1 increases affinity for DCUN1D3 by about 2 orders of magnitude and is crucial for NEDD8 transfer to cullins.
Function	Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. Together with the E3 ubiquitin ligase RNF7/RBX2, specifically neddylates cullin-5 (CUL5). Does not neddylate CUL1, CUL2, CUL3, CUL4A or CUL4B. Mediates neddylation of the CUL9-RBX1 complex. (Microbial infection) Following infection by HIV-1 virus, participates to HIV-1 Vif protein-mediated ubiquitination and degradation of APOBEC3G by mediating neddylation of cullin-5 (CUL5).
Protein Name	Nedd8-Conjugating Enzyme Ube2f Nedd8 Carrier Protein Ube2f Nedd8 Protein Ligase Ube2f Nedd8-Conjugating Enzyme 2 Ring-Type E3 Nedd8 Transferase Ube2f Ubiquitin-Conjugating Enzyme E2 F
Database Links	Reactome: R-HSA-8951664 Reactome: R-HSA-983168
Cellular Localisation
Alternative Protein Names	Nedd8-Conjugating Enzyme Ube2f protein Nedd8 Carrier Protein Ube2f protein Nedd8 Protein Ligase Ube2f protein Nedd8-Conjugating Enzyme 2 protein Ring-Type E3 Nedd8 Transferase Ube2f protein Ubiquitin-Conjugating Enzyme E2 F protein UBE2F protein NCE2 protein

Information sourced from Uniprot.org