| Tissue Specificity | Abundantly expressed in whole adult brain and in all individual brain regions examined, including spinal cord. Weakly expressed in ovary, testis, fetal brain and small intestine. |
| Post Translational Modifications | Palmitoylated. Palmitoylation by ZDHHC1, ZDHHC3 and ZDHHC11 regulates the association of NCDN with endosome membranes. May also be palmitoylated by ZDHHC7. |
| Function | Probably involved in signal transduction in the nervous system, via increasing cell surface localization of GRM5/mGluR5 and positively regulating its signaling. Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth (Probable). |
| Protein Name | Neurochondrin |
| Database Links | |
| Cellular Localisation | CytoplasmCytosolEndosome MembraneLipid-AnchorCell ProjectionDendritePostsynapseLocalizes To Somatic Regions Of NeuronsLocalization To Endosome Membrane Requires Palmitoylation |
| Alternative ELISA Names | Neurochondrin ELISA kitNCDN ELISA kitKIAA0607 ELISA kit |
| output | |
Information sourced from Uniprot.org
