Human NCAD (Cadherin-2) Antibody Pair (STJAP00189)
General Information
| Short Description | This NCAD antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA. |
| Applications | ELISA |
| Host | Sheep/Sheep |
| Reactivity | Human |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Polyclonal/Polyclonal |
| Conjugation | Unconjugated/Biotin |
| Concentration | 0.5 mg/mL |
| Purification | Capture Purification: Antigen Affinity.Detection Purification: Antigen Affinity. |
| Formulation | Capture Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.Detection Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4. |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | CDH2 |
| Gene ID | 1000 |
| Uniprot ID | CADH2_HUMAN |
| Immunogen | Capture immunogen: Recombinant Human NCAD protein.Detection Immunogen: Recombinant Human NCAD protein. |
Additional Info
| Function | Calcium-dependent cell adhesion protein.preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. Plays a role in cell-to-cell junction formation between pancreatic beta cells and neural crest stem (NCS) cells, promoting the formation of processes by NCS cells. Required for proper neurite branching. Required for pre- and postsynaptic organization. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. |
| Protein Name | Cadherin-2Cdw325Neural CadherinN-CadherinCd Antigen Cd325 |
| Database Links | Reactome: R-HSA-381426Reactome: R-HSA-418990Reactome: R-HSA-525793Reactome: R-HSA-8957275Reactome: R-HSA-9926550 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinSarcolemmaCell JunctionCell SurfaceDesmosomeAdherens JunctionColocalizes With Tmem65 At The Intercalated Disk In CardiomyocytesColocalizes With Obscn At The Intercalated Disk And At Sarcolemma In Cardiomyocytes |
| Alternative Antibody Pair Names | Cadherin-2 antibody pairCdw325 antibody pairNeural Cadherin antibody pairN-Cadherin antibody pairCd Antigen Cd325 antibody pairCDH2 antibody pairCDHN antibody pairNCAD antibody pair |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about Human NCAD (Cadherin-2) Antibody Pair (STJAP00189)
This antibody pair detects human NCAD (Cadherin-2, UniProt P19022). Reactivity is confirmed for human samples only.
Both antibodies are polyclonal, raised in sheep, and purified by antigen affinity. The capture antibody is unconjugated, while the detection antibody is biotinylated. Both are supplied at 0.5 mg/mL.
This antibody pair is validated for ELISA. No other assay formats are listed in the product specifications.
Both the capture and detection antibodies were raised against recombinant human NCAD protein. No specific immunogen region is defined in the product specifications.
Both the capture and detection antibodies are formulated in PBS with 0.04% Proclin 300 and 50% glycerol at pH 7.4. Both components should be stored at -20°C for long-term storage, and freeze-thaw cycles should be avoided.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.