Human MYL9 protein (Recombinant) (His-Tag) (STJP017060)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human MYL9-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 1mM DTT, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MYL9 |
| Gene ID | 10398 |
| Uniprot ID | MYL9_HUMAN |
| Accession Number | NP_006088 |
| Immunogen | Human |
| Immunogen Region | 1-172aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Smooth muscle tissues and in some, but not all, nonmuscle cells. |
| Post Translational Modifications | Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity. It is required to generate the driving force in the migration of the cells but not necessary for localization of myosin-2 at the leading edge. Phosphorylation is required for myotube formation. Phosphorylated by DAPK3.DAPK3-mediated phosphorylation is inhibited by LUZP1. |
| Function | Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion. In myoblasts, may regulate PIEZO1-dependent cortical actomyosin assembly involved in myotube formation. |
| Protein Name | Myosin Regulatory Light Polypeptide 920 Kda Myosin Light ChainLc20Mlc-2cMyosin RlcMyosin Regulatory Light Chain 2 - Smooth Muscle IsoformMyosin Regulatory Light Chain 9Myosin Regulatory Light Chain Mrlc1 |
| Database Links | Reactome: R-HSA-3928663Reactome: R-HSA-416572Reactome: R-HSA-445355Reactome: R-HSA-5625740Reactome: R-HSA-5625900Reactome: R-HSA-5627117Reactome: R-HSA-5627123Reactome: R-HSA-8936459 |
| Cellular Localisation | CytoplasmCytoskeletonCell CortexColocalizes With F-ActinMyh9 And Piezo1 At The Actomyosin Cortex In Myoblasts |
| Alternative Protein Names | Myosin Regulatory Light Polypeptide 9 protein20 Kda Myosin Light Chain proteinLc20 proteinMlc-2c proteinMyosin Rlc proteinMyosin Regulatory Light Chain 2 - Smooth Muscle Isoform proteinMyosin Regulatory Light Chain 9 proteinMyosin Regulatory Light Chain Mrlc1 proteinMYL9 proteinMLC2 proteinMRLC1 proteinMYRL2 protein |
Information sourced from Uniprot.org