Human MXRA8 protein (Recombinant) (N-His) (STJP010997)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human MXRA8-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | MXRA8 |
| Gene ID | 54587 |
| Uniprot ID | MXRA8_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | His23-Glu293 |
Additional Info
| Function | Transmembrane protein which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3. Mediates heterophilic cell-cell interactions in vitro. Inhibits osteoclastogenesis downstream of TNFSF11/RANKL and CSF1, where it may function by attenuating signaling via integrin ITGB3 and MAP kinase p38. Plays a role in cartilage formation where it promotes proliferation and maturation of growth plate chondrocytes. Stimulates formation of primary cilia in chondrocytes. Enhances expression of genes involved in the hedgehog signaling pathway in chondrocytes, including the hedgehog signaling molecule IHH.may also promote signaling via the PTHLH/PTHrP pathway. Plays a role in angiogenesis where it suppresses migration of endothelial cells and also promotes their apoptosis. Inhibits VEGF-induced activation of AKT and p38 MAP kinase in endothelial cells. Also inhibits VTN (vitronectin)-mediated integrin ITGAV:ITGB3 signaling and activation of PTK2/FAK. May play a role in the maturation and maintenance of the blood-brain barrier. (Microbial infection) Contributes to arthritogenic alphavirus pathogenesis and acts as a receptor for these viruses. |
| Protein Name | Matrix Remodeling-Associated Protein 8Limitrin |
| Database Links | Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell JunctionTight JunctionCytoplasmCell ProjectionCilium MembraneNucleusPrimarily Localizes To The Cell MembraneDetected In The Cilium Of Primary ChondrocytesHighly Expressed At Areas Of Cell-Cell Contact And May Localize To Tight JunctionsAlso Found In The Nucleus Where It Is Detected In The Soluble (As Opposed To Chromatin-Bound) Fraction |
| Alternative Protein Names | Matrix Remodeling-Associated Protein 8 proteinLimitrin proteinMXRA8 protein |
Information sourced from Uniprot.org