Human MTR (5-Methyltetrahydrofolate Homocysteine Methyltransferase) Sandwich ELISA Kit (STJE0010771)
SPECIFICATIONS
General Information
| Short Description | This MTR Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human serum, plasma, tissue homogenates or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Human |
| Sensitivity | 0.115ng/mL |
| Detection Limit | 0.312-20ng/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 4.5 hrs |
Target Information
| Gene Symbol | MTR |
| Gene ID | 4548 |
| Uniprot ID | METH_HUMAN |
| Sample Type | serum, plasma, tissue homogenates or other biological fluids. |
Additional Info
| Tissue Specificity | Widely expressed. Expressed at the highest levels in pancreas, heart, brain, skeletal muscle and placenta. Expressed at lower levels in lung, liver and kidney. |
| Post Translational Modifications | |
| Function | Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol. MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine. |
| Protein Name | Methionine SynthaseMs5-Methyltetrahydrofolate--Homocysteine MethyltransferaseCobalamin-Dependent Methionine SynthaseVitamin-B12 Dependent Methionine Synthase |
| Database Links | Reactome: R-HSA-156581Reactome: R-HSA-1614635Reactome: R-HSA-3359467Reactome: R-HSA-3359469Reactome: R-HSA-9013407Reactome: R-HSA-9759218 |
| Cellular Localisation | Cytoplasm |
| Alternative ELISA Names | Methionine Synthase ELISA kitMs ELISA kit5-Methyltetrahydrofolate--Homocysteine Methyltransferase ELISA kitCobalamin-Dependent Methionine Synthase ELISA kitVitamin-B12 Dependent Methionine Synthase ELISA kitMTR ELISA kit |
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Information sourced from Uniprot.org