Human MR (Mineralocorticoid Receptor) Sandwich ELISA Kit (STJE0010724)
SPECIFICATIONS
General Information
| Short Description | This MR Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates, cell lysates or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Human |
| Sensitivity | 0.112ng/mL |
| Detection Limit | 0.312-20ng/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 4.5 hrs |
Target Information
| Gene Symbol | NR3C2 |
| Gene ID | 4306 |
| Uniprot ID | MCR_HUMAN |
| Sample Type | tissue homogenates, cell lysates or other biological fluids. |
Additional Info
| Tissue Specificity | Ubiquitous. Highly expressed in distal tubules, convoluted tubules and cortical collecting duct in kidney, and in sweat glands. Detected at lower levels in cardiomyocytes, in epidermis and in colon enterocytes. |
| Post Translational Modifications | Phosphorylated. |
| Function | Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels. |
| Protein Name | Mineralocorticoid ReceptorMrNuclear Receptor Subfamily 3 Group C Member 2 |
| Database Links | Reactome: R-HSA-3371497Reactome: R-HSA-383280Reactome: R-HSA-4090294 |
| Cellular Localisation | CytoplasmNucleusEndoplasmic Reticulum MembranePeripheral Membrane ProteinCytoplasmic And Nuclear In The Absence Of LigandNuclear After Ligand-BindingWhen Bound To Hsd11b2It Is Found Associated With The Endoplasmic Reticulum Membrane |
| Alternative ELISA Names | Mineralocorticoid Receptor ELISA kitMr ELISA kitNuclear Receptor Subfamily 3 Group C Member 2 ELISA kitNR3C2 ELISA kitMCR ELISA kitMLR ELISA kit |
| output |
Information sourced from Uniprot.org