Human MORF4L2 protein (Recombinant) (His-Tag) (STJP017124)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human MORF4L2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MORF4L2 |
| Gene ID | 9643 |
| Uniprot ID | MO4L2_HUMAN |
| Accession Number | NP_036418 |
| Immunogen | Human |
| Immunogen Region | 1-288aa |
| Immunogen Sequence |
Additional Info
| Function | Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also a component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones. |
| Protein Name | Mortality Factor 4-Like Protein 2Morf-Related Gene X ProteinProtein Msl3-2Transcription Factor-Like Protein Mrgx |
| Database Links | Reactome: R-HSA-3214847 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Mortality Factor 4-Like Protein 2 proteinMorf-Related Gene X Protein proteinProtein Msl3-2 proteinTranscription Factor-Like Protein Mrgx proteinMORF4L2 proteinKIAA0026 proteinMRGX protein |
Information sourced from Uniprot.org