Human MOB1B protein (Recombinant) (N-His) (STJP008011)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human MOB1B-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | MOB1B |
| Gene ID | 92597 |
| Uniprot ID | MOB1B_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser23-Arg216 |
Additional Info
| Post Translational Modifications | Phosphorylated by STK3/MST2 and STK4/MST1 and this phosphorylation enhances its binding to LATS1. |
| Function | Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L. |
| Protein Name | Mob Kinase Activator 1bMob1 Homolog 1aMob1aMob1bMps One Binder Kinase Activator-Like 1a |
| Database Links | Reactome: R-HSA-2028269 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Protein Names | Mob Kinase Activator 1b proteinMob1 Homolog 1a proteinMob1a proteinMob1b proteinMps One Binder Kinase Activator-Like 1a proteinMOB1B proteinMOB4A proteinMOBKL1A protein |
Information sourced from Uniprot.org