Human MOB1A protein (Recombinant) (C-His) (STJP014753)
SPECIFICATIONS
HostE.coli
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human MOB1A-C-His protein was developed from e.coli and has a target region of C-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a 0.22 Mu m filtered solution in 20mM Glycine, 8% Trehalose, 2% Mannitol, 150mM NaCl, 0.03% Tween 80, pH 3.5. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | < 1 EU/µg as determined by LAL test. |
Target Information
| Gene Symbol | MOB1A |
| Gene ID | 55233 |
| Uniprot ID | MOB1A_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser2-Arg216 |
Additional Info
| Post Translational Modifications | Phosphorylated by STK3/MST2 and STK4/MST1 and this phosphorylation enhances its binding to LATS1. |
| Function | Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38. |
| Protein Name | Mob Kinase Activator 1aMob1 AlphaMob1aMob1 Homolog 1bMps One Binder Kinase Activator-Like 1b |
| Database Links | Reactome: R-HSA-2028269 |
| Cellular Localisation | |
| Alternative Protein Names | Mob Kinase Activator 1a proteinMob1 Alpha proteinMob1a proteinMob1 Homolog 1b proteinMps One Binder Kinase Activator-Like 1b proteinMOB1A proteinC2orf6 proteinMOB4B proteinMOBK1B proteinMOBKL1B protein |
Information sourced from Uniprot.org