Human MMS2/UBE2V2 protein (Recombinant) (His-Tag) (STJP016782)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human MMS2/UBE2V2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol 0.1M NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | UBE2V2 |
| Gene ID | 7336 |
| Uniprot ID | UB2V2_HUMAN |
| Accession Number | NP_003341 |
| Immunogen | Human |
| Immunogen Region | 1-145aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Detected in placenta, colon, liver and skin. Detected at very low levels in most tissues. |
| Function | Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. |
| Protein Name | Ubiquitin-Conjugating Enzyme E2 Variant 2Ddvit 1Enterocyte Differentiation-Associated Factor 1Edaf-1Enterocyte Differentiation-Promoting Factor 1Edpf-1Mms2 HomologVitamin D3-Inducible Protein |
| Database Links | Reactome: R-HSA-5693565Reactome: R-HSA-5693571Reactome: R-HSA-5693607Reactome: R-HSA-5696395Reactome: R-HSA-69473Reactome: R-HSA-8866654Reactome: R-HSA-983168 |
| Cellular Localisation | |
| Alternative Protein Names | Ubiquitin-Conjugating Enzyme E2 Variant 2 proteinDdvit 1 proteinEnterocyte Differentiation-Associated Factor 1 proteinEdaf-1 proteinEnterocyte Differentiation-Promoting Factor 1 proteinEdpf-1 proteinMms2 Homolog proteinVitamin D3-Inducible Protein proteinUBE2V2 proteinMMS2 proteinUEV2 protein |
Information sourced from Uniprot.org