Human MMRN1 protein (Recombinant) (N-His) (STJP005300)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human MMRN1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | MMRN1 |
| Gene ID | 22915 |
| Uniprot ID | MMRN1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ala807-Gly1053 |
Additional Info
| Post Translational Modifications | The N-terminus is blocked. Extensively N-glycosylated. O-fucosylated within the EMI domain (at Thr-216 and Thr-265) by FUT10/POFUT3 and FUT11/POFUT4. O-fucosylation at Thr-216 and Thr-1055 are required for facilitating protein folding and secretion. |
| Function | Carrier protein for platelet (but not plasma) factor V/Va. Plays a role in the storage and stabilization of factor V in platelets. Upon release following platelet activation, may limit platelet and plasma factor Va-dependent thrombin generation. Ligand for integrin alpha-IIb/beta-3 and integrin alpha-V/beta-3 on activated platelets, and may function as an extracellular matrix or adhesive protein. |
| Protein Name | Multimerin-1Emilin-4Elastin Microfibril Interface Located Protein 4Elastin Microfibril Interfacer 4Endothelial Cell Multimerin Cleaved Into - Platelet Glycoprotein Ia* - 155 Kda Platelet MultimerinP-155P155 |
| Database Links | Reactome: R-HSA-114608 |
| Cellular Localisation | SecretedO-Fucosylation Of Thr-216 And Thr-1055 Is Important For Protein Secretion |
| Alternative Protein Names | Multimerin-1 proteinEmilin-4 proteinElastin Microfibril Interface Located Protein 4 proteinElastin Microfibril Interfacer 4 proteinEndothelial Cell Multimerin Cleaved Into - Platelet Glycoprotein Ia* - 155 Kda Platelet Multimerin proteinP-155 proteinP155 proteinMMRN1 proteinECM proteinEMILIN4 proteinGPIA* proteinMMRN protein |
Information sourced from Uniprot.org