Human MMP9 protein (Recombinant-Active) (C-His) (STJP011874)

Name: Human MMP9 protein (Recombinant-Active) (C-His) (STJP011874)
SKU: STJP011874-100
Price: 503.5 GBP
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostMammalian Cells

ConjugationUnconjugated

ImmunogenHomo sapiens (Human)

STJP011874-100

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Short Description	Recombinant-Active-Human MMP9-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Applications	ELISA/WB
Host	Mammalian Cells
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Conjugation	Unconjugated
Dilution Range	Reconstitute in sterile water for a stock solution.
Formulation	Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Storage Instruction	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin	<0.1 EU/Mu g of the protein by the LAL method.
Immunoreactivity	Measured in a cell migration assay using A549 cells. 1 ng/mL of recombinant human MMP9 can effectively induce A549 cells migration.2.Measured by its ability to cleave the fluorogenic peptide substrate Mca-PLGL-Dpa-ARNH2.The specific activity is >1100

Post Translational Modifications	Processing of the precursor yields different active forms of 64, 67 and 82 kDa. Sequentially processing by MMP3 yields the 82 kDa matrix metalloproteinase-9. N- and O-glycosylated.
Function	Matrix metalloproteinase that plays an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-\|-Leu bond. Cleaves NINJ1 to generate the Secreted ninjurin-1 form. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.
Protein Name	Matrix Metalloproteinase-9 Mmp-9 92 Kda Gelatinase 92 Kda Type Iv Collagenase Gelatinase B Gelb Cleaved Into - 67 Kda Matrix Metalloproteinase-9 - 82 Kda Matrix Metalloproteinase-9
Database Links	Reactome: R-HSA-1433557 Reactome: R-HSA-1442490 Reactome: R-HSA-1474228 Reactome: R-HSA-1592389 Reactome: R-HSA-2022090 Reactome: R-HSA-3928665 Reactome: R-HSA-6785807 Reactome: R-HSA-6798695 Reactome: R-HSA-9009391
Cellular Localisation	Secreted Extracellular Space Extracellular Matrix
Alternative Protein Names	Matrix Metalloproteinase-9 protein Mmp-9 protein 92 Kda Gelatinase protein 92 Kda Type Iv Collagenase protein Gelatinase B protein Gelb Cleaved Into - 67 Kda Matrix Metalloproteinase-9 - 82 Kda Matrix Metalloproteinase-9 protein MMP9 protein CLG4B protein

Information sourced from Uniprot.org