Human MMP24 protein (Recombinant) (N-His) (STJP006281)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human MMP24-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | MMP24 |
| Gene ID | 10893 |
| Uniprot ID | MMP24_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ile429-Gln642 |
Additional Info
| Post Translational Modifications | Cleaved by a furin endopeptidase in the trans-Golgi network. |
| Function | Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence. May play a role in axonal growth. Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin. |
| Protein Name | Matrix Metalloproteinase-24Mmp-24Membrane-Type Matrix Metalloproteinase 5Mt-Mmp 5Mtmmp5Membrane-Type-5 Matrix MetalloproteinaseMt5-MmpMt5mmp Cleaved Into - Processed Matrix Metalloproteinase-24 |
| Database Links | Reactome: R-HSA-1592389 |
| Cellular Localisation | Matrix Metalloproteinase-24: Cell MembraneSingle-Pass Type I Membrane ProteinGolgi ApparatusTrans-Golgi Network MembraneRecycled Back To The Plasma Membrane Through The Trans-Golgi Network Via Interaction With Apba3Processed Matrix Metalloproteinase-24: SecretedExtracellular SpaceExtracellular MatrixAlso Shed From Cell Surface As Soluble ProteinaseBy A Proteolytic Cleavage |
| Alternative Protein Names | Matrix Metalloproteinase-24 proteinMmp-24 proteinMembrane-Type Matrix Metalloproteinase 5 proteinMt-Mmp 5 proteinMtmmp5 proteinMembrane-Type-5 Matrix Metalloproteinase proteinMt5-Mmp proteinMt5mmp Cleaved Into - Processed Matrix Metalloproteinase-24 proteinMMP24 proteinMT5MMP protein |
Information sourced from Uniprot.org