Human MMP17 protein (Recombinant-Active) (C-His) (STJP012321)

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STJP012321-100
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Host: Mammalian Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Active-Human MMP17-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Dilution Range: Reconstitute in sterile water for a stock solution.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: <0.1 EU/Mu g of the protein by the LAL method.
Gene Symbol: MMP17
Gene ID: 4326
Uniprot ID: MMP17_HUMAN
Immunogen Region: Ala39-Ser531 (Arg125Pro, Ala182Thr)
Immunogen: Homo sapiens (Human)
Post Translational Modifications The precursor is cleaved by a furin endopeptidase.
Function Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Cleaves pro-TNF-alpha at the '74-Ala-|-Gln-75' site. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin.
Protein Name Matrix Metalloproteinase-17
Mmp-17
Membrane-Type Matrix Metalloproteinase 4
Mt-Mmp 4
Mtmmp4
Membrane-Type-4 Matrix Metalloproteinase
Mt4-Mmp
Mt4mmp
Database Links Reactome: R-HSA-1592389
Cellular Localisation Isoform Long: Cell Membrane
Lipid-Anchor
Gpi-Anchor
Extracellular Side
Secreted
Extracellular Space
Extracellular Matrix
Alternative Protein Names Matrix Metalloproteinase-17 protein
Mmp-17 protein
Membrane-Type Matrix Metalloproteinase 4 protein
Mt-Mmp 4 protein
Mtmmp4 protein
Membrane-Type-4 Matrix Metalloproteinase protein
Mt4-Mmp protein
Mt4mmp protein
MMP17 protein
MT4MMP protein

Information sourced from Uniprot.org

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