Human MMP14 protein (Recombinant) (C-His) (STJP013352)
SPECIFICATIONS
HostMammalian cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human MMP14-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for this information. |
Target Information
| Gene Symbol | MMP14 |
| Gene ID | 4323 |
| Uniprot ID | MMP14_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ala21-Ser538 (Arg108Pro) |
Additional Info
| Post Translational Modifications | The precursor is cleaved by a furin endopeptidase. Tyrosine phosphorylated by PKDCC/VLK. |
| Function | Endopeptidase that degrades various components of the extracellular matrix such as collagen. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. Activates progelatinase A/MMP2, thereby acting as a positive regulator of cell growth and migration. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a regulator of Notch signaling by mediating cleavage and inhibition of DLL1. Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis. Acts as a negative regulator of the GDF15-GFRAL aversive response by mediating cleavage and inactivation of GFRAL. |
| Protein Name | Matrix Metalloproteinase-14Mmp-14Mmp-X1Membrane-Type Matrix Metalloproteinase 1Mt-Mmp 1Mtmmp1Membrane-Type-1 Matrix MetalloproteinaseMt1-MmpMt1mmp |
| Database Links | Reactome: R-HSA-1442490Reactome: R-HSA-1474228Reactome: R-HSA-1592389Reactome: R-HSA-9839383Reactome: R-HSA-9856530 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinMelanosomeCytoplasmIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage IvForms A Complex With Bst2 And Localizes To The Cytoplasm |
| Alternative Protein Names | Matrix Metalloproteinase-14 proteinMmp-14 proteinMmp-X1 proteinMembrane-Type Matrix Metalloproteinase 1 proteinMt-Mmp 1 proteinMtmmp1 proteinMembrane-Type-1 Matrix Metalloproteinase proteinMt1-Mmp proteinMt1mmp proteinMMP14 protein |
Information sourced from Uniprot.org