Human MMP12 protein (Recombinant-Active) (No tag) (STJP011983)

SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
STJP011983-100
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General Information

Short DescriptionRecombinant-Active-Human MMP12-No tag protein was developed from mammalian cells and has a target region of No tag. For use in research applications.
ApplicationsELISA/WB
HostMammalian Cells
NoteSTRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Product Properties

ConjugationUnconjugated
Dilution RangeReconstitute in sterile water for a stock solution.
FormulationLyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Storage InstructionUse a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin<0.1 EU/Mu g of the protein by the LAL method.
ImmunoreactivityMeasured by its ability to cleave the fluorogenic peptide substrate, McaPLGL-Dpa-ARNH2. The specific activity is >800 pmol/min/Mu g.

Target Information

Gene SymbolMMP12
Gene ID4321
Uniprot IDMMP12_HUMAN
ImmunogenHomo sapiens (Human)
Immunogen RegionGly106-Asn268

Additional Info

Function May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.
Protein Name Macrophage Metalloelastase
Mme
Macrophage Elastase
Me
Hme
Matrix Metalloproteinase-12
Mmp-12
Database Links Reactome: R-HSA-1442490
Reactome: R-HSA-1474228
Cellular Localisation Secreted
Extracellular Space
Extracellular Matrix
Alternative Protein Names Macrophage Metalloelastase protein
Mme protein
Macrophage Elastase protein
Me protein
Hme protein
Matrix Metalloproteinase-12 protein
Mmp-12 protein
MMP12 protein
HME protein

Information sourced from Uniprot.org

Citations

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