Human MMP12 protein (Recombinant-Active) (No tag) (STJP011983)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Active-Human MMP12-No tag protein was developed from mammalian cells and has a target region of No tag. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity | Measured by its ability to cleave the fluorogenic peptide substrate, McaPLGL-Dpa-ARNH2. The specific activity is >800 pmol/min/Mu g. |
Target Information
| Gene Symbol | MMP12 |
| Gene ID | 4321 |
| Uniprot ID | MMP12_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gly106-Asn268 |
Additional Info
| Function | May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3. |
| Protein Name | Macrophage MetalloelastaseMmeMacrophage ElastaseMeHmeMatrix Metalloproteinase-12Mmp-12 |
| Database Links | Reactome: R-HSA-1442490Reactome: R-HSA-1474228 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Protein Names | Macrophage Metalloelastase proteinMme proteinMacrophage Elastase proteinMe proteinHme proteinMatrix Metalloproteinase-12 proteinMmp-12 proteinMMP12 proteinHME protein |
Information sourced from Uniprot.org