Human MMADHC protein (Recombinant) (His-Tag) (STJP018629)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human MMADHC-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MMADHC |
| Gene ID | 27249 |
| Uniprot ID | MMAD_HUMAN |
| Accession Number | NP_056517 |
| Immunogen | Human |
| Immunogen Region | 39-296aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSSDESHVA AAPPDICSRT VWPDETMGPF GPQDQRFQLP GNIGFDCHLN GTASQKKSLV HKTLPDVLAE PLSSERHEFV MAQYVNEFQG NDAPVEQEIN SAETYFESAR VECAIQTCPE LLRKDFESLF PEVANGKLMI LTVTQKTKND MTVWSEEVEI EREVLLEKFI NGAKEICYAL RAEGYWADFI DPSSGLAFFG PYTNNTLF |
Additional Info
| Tissue Specificity | Widely expressed at high levels. |
| Function | Involved in cobalamin metabolism and trafficking. Plays a role in regulating the biosynthesis and the proportion of two coenzymes, methylcob(III)alamin (MeCbl) and 5'-deoxyadenosylcobalamin (AdoCbl). Promotes oxidation of cob(II)alamin bound to MMACHC. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR (methionine synthase) which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine. |
| Protein Name | Cobalamin Trafficking Protein CbldCbldMethylmalonic Aciduria And Homocystinuria Type D Protein - Mitochondrial |
| Database Links | Reactome: R-HSA-3359473Reactome: R-HSA-9759218 |
| Cellular Localisation | CytoplasmMitochondrion |
| Alternative Protein Names | Cobalamin Trafficking Protein Cbld proteinCbld proteinMethylmalonic Aciduria And Homocystinuria Type D Protein - Mitochondrial proteinMMADHC proteinC2orf25 proteinCL25022 proteinHSPC161 proteinMy011 protein |
Information sourced from Uniprot.org