Human MLF1IP protein (Recombinant) (His-Tag) (STJP018595)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human MLF1IP-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Denatured |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol, 0.4M urea |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CENPU |
| Gene ID | 79682 |
| Uniprot ID | CENPU_HUMAN |
| Accession Number | NP_078905 |
| Immunogen | Human |
| Immunogen Region | 147-418a |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Expressed at high levels in the testis, fetal liver, thymus, bone marrow and at lower levels in the lymph nodes, placenta, colon and spleen. Present in all cell lines examined, including B-cells, T-cells, epithelial cells and fibroblast cells. Expressed at high levels in glioblastoma cell lines. |
| Post Translational Modifications | Phosphorylated by PLK1 at Thr-78, creating a self-tethering site that specifically interacts with the polo-box domain of PLK1. |
| Function | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression. |
| Protein Name | Centromere Protein UCenp-UCentromere Protein Of 50 KdaCenp-50Interphase Centromere Complex Protein 24Kshv Latent Nuclear Antigen-Interacting Protein 1Mlf1-Interacting ProteinPolo-Box-Interacting Protein 1 |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-5663220Reactome: R-HSA-606279Reactome: R-HSA-68877Reactome: R-HSA-9648025 |
| Cellular Localisation | CytoplasmNucleusChromosomeCentromereKinetochoreLocalizes In The Kinetochore Domain Of CentromeresColocalizes With Plk1 At The Interzone Between The Inner And The Outer Kinetochore Plates |
| Alternative Protein Names | Centromere Protein U proteinCenp-U proteinCentromere Protein Of 50 Kda proteinCenp-50 proteinInterphase Centromere Complex Protein 24 proteinKshv Latent Nuclear Antigen-Interacting Protein 1 proteinMlf1-Interacting Protein proteinPolo-Box-Interacting Protein 1 proteinCENPU proteinICEN24 proteinKLIP1 proteinMLF1IP proteinPBIP1 protein |
Information sourced from Uniprot.org