Human MKRN3 (Makorin Ring Finger Protein 3) Sandwich ELISA Kit Ready-To-Use Kit (STJE0017014)
SPECIFICATIONS
General Information
| Short Description | This MKRN3 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human serum, plasma, tissue homogenates or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Human |
| Sensitivity | 0.71ng/mL |
| Detection Limit | 1.56-100ng/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 3 hrs |
Target Information
| Gene Symbol | MKRN3 |
| Gene ID | 7681 |
| Uniprot ID | MKRN3_HUMAN |
| Immunogen Region | Ready-To-Use |
| Sample Type | serum, plasma, tissue homogenates or other biological fluids. |
Additional Info
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | |
| Function | E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Acts as a key developmental timer that helps ensure puberty begins at the appropriate age, by inhibiting premature activation of the reproductive hormone cascade. Epigenetically regulates GNRH1 transcription by disrupting the binding of methyl-DNA binding protein 3/MBD3 to the promoter of GNRH1. Mechanistically, mediates the non-proteolytic ubiquitination of MBD3 at multiple sites with 'Lys27' ubiquitin linkages and thereby regulates the methylation status of the genome, including GNRH1 promoter. Modulates the stability and translation of GNRH1 mRNA by mediating the non-proteolytic ubiquitination of PABP family members PABPC1, PABPC3 and PABPC4 at multiple sites. Also participates in the maintenance of genomic and epigenomic stability by regulating the abundance of APEX2 via 'Lys-48'-linked ubiquitination. |
| Protein Name | E3 Ubiquitin-Protein Ligase Makorin-3Ring Finger Protein 63Ring-Type E3 Ubiquitin Transferase Makorin-3Zinc Finger Protein 127 |
| Database Links | |
| Cellular Localisation | Nucleus |
| Alternative ELISA Names | E3 Ubiquitin-Protein Ligase Makorin-3 ELISA kitRing Finger Protein 63 ELISA kitRing-Type E3 Ubiquitin Transferase Makorin-3 ELISA kitZinc Finger Protein 127 ELISA kitMKRN3 ELISA kitD15S9 ELISA kitRNF63 ELISA kitZNF127 ELISA kit |
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Information sourced from Uniprot.org