Human MKK3 protein (Recombinant) (His-Tag) (STJP017136)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human MKK3-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MAP2K3 |
| Gene ID | 5606 |
| Uniprot ID | MP2K3_HUMAN |
| Accession Number | NP_002747.2 |
| Immunogen | Human |
| Immunogen Region | 1-318aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues. |
| Post Translational Modifications | Autophosphorylated. Phosphorylation on Ser-218 and Thr-222 by MAP kinase kinase kinases positively regulates the kinase activity. Phosphorylated by TAOK2. (Microbial infection) Yersinia YopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway. |
| Function | Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. |
| Protein Name | Dual Specificity Mitogen-Activated Protein Kinase Kinase 3Map Kinase Kinase 3Mapkk 3Mapk/Erk Kinase 3Mek 3Stress-Activated Protein Kinase Kinase 2Sapk Kinase 2Sapkk-2Sapkk2 |
| Database Links | Reactome: R-HSA-2559580Reactome: R-HSA-450302Reactome: R-HSA-5210891 P46734-3 |
| Cellular Localisation | |
| Alternative Protein Names | Dual Specificity Mitogen-Activated Protein Kinase Kinase 3 proteinMap Kinase Kinase 3 proteinMapkk 3 proteinMapk/Erk Kinase 3 proteinMek 3 proteinStress-Activated Protein Kinase Kinase 2 proteinSapk Kinase 2 proteinSapkk-2 proteinSapkk2 proteinMAP2K3 proteinMEK3 proteinMKK3 proteinPRKMK3 proteinSKK2 protein |
Information sourced from Uniprot.org