Human MIP-1 beta (MIP-1 beta) Antibody Pair (STJAP00754)
General Information
| Short Description | This MIP-1 beta antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the. |
| Applications | ELISA |
| Host | Rabbit/Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal/Monoclonal |
| Clone ID | R06-2O6/R08-5V7 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | Determined by end user |
| Formulation | 0.01M PBS, pH 7.2 |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | CCL4 |
| Gene ID | 388372/6351 |
| Uniprot ID | CCL4_HUMAN |
| Immunogen | Recombinant protein |
Additional Info
| Post Translational Modifications | N-terminal processed form MIP-1-beta(3-69) is produced by proteolytic cleavage after secretion from peripheral blood lymphocytes. |
| Function | Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B. |
| Protein Name | C-C Motif Chemokine 4G-26 T-Lymphocyte-Secreted ProteinHc21Lymphocyte Activation Gene 1 ProteinLag-1Mip-1-Beta(1-69Macrophage Inflammatory Protein 1-BetaMip-1-BetaPat 744Protein H400Sis-GammaSmall-Inducible Cytokine A4T-Cell Activation Protein 2Act-2 Cleaved Into - Mip-1-Beta(3-69 |
| Database Links | Reactome: R-HSA-380108Reactome: R-HSA-418594Reactome: R-HSA-6783783 |
| Cellular Localisation | Secreted |
| Alternative Antibody Pair Names | C-C Motif Chemokine 4 antibody pairG-26 T-Lymphocyte-Secreted Protein antibody pairHc21 antibody pairLymphocyte Activation Gene 1 Protein antibody pairLag-1 antibody pairMip-1-Beta(1-69 antibody pairMacrophage Inflammatory Protein 1-Beta antibody pairMip-1-Beta antibody pairPat 744 antibody pairProtein H400 antibody pairSis-Gamma antibody pairSmall-Inducible Cytokine A4 antibody pairT-Cell Activation Protein 2 antibody pairAct-2 Cleaved Into - Mip-1-Beta(3-69 antibody pairCCL4 antibody pairLAG1 antibody pairMIP1B antibody pairSCYA4 antibody pair |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about Human MIP-1 beta (MIP-1 beta) Antibody Pair (STJAP00754)
This antibody pair detects human MIP-1 beta (CCL4, UniProt P13236) and is validated for reactivity with human samples only. Both antibodies were raised against recombinant protein immunogen.
This antibody pair is validated for use in ELISA. It is intended for research use only and is not validated for diagnostic or therapeutic applications.
Both antibodies are rabbit monoclonal IgGs supplied unconjugated at 1 mg/mL in 0.01M PBS, pH 7.2, and are affinity purified. Clone IDs are R06-2O6 and R08-5V7 respectively.
Working dilutions for both the capture and detection antibodies are to be determined by the end user, as optimal concentrations will depend on the specific assay format and experimental conditions.
Both antibodies should be stored at 4°C for short-term use. For long-term storage, aliquot and store at -20°C. Repeated freeze/thaw cycles should be avoided to preserve antibody integrity.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.