Human MINA protein (Recombinant) (His-Tag) (STJP018898)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human MINA-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RIOX2 |
| Gene ID | 84864 |
| Uniprot ID | RIOX2_HUMAN |
| Accession Number | AAH14928 |
| Immunogen | Human |
| Immunogen Region | 1-465aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Expressed in liver, skeletal muscle, heart, pancreas, and placenta. Not detected in brain, lung or kidney. Expressed in several lung cancer tissues, but is barely detected in the adjacent non-cancerous tissues. Also highly expressed in several esophageal squamous cell carcinoma (ESCC), and colon cancer tissues, and in various cancer cell lines. |
| Function | Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles. |
| Protein Name | Ribosomal Oxygenase 260s Ribosomal Protein L27a Histidine HydroxylaseBifunctional Lysine-Specific Demethylase And Histidyl-Hydroxylase MinaHistone Lysine Demethylase MinaMyc-Induced Nuclear AntigenMineral Dust-Induced Gene ProteinNucleolar Protein 52Ribosomal Oxygenase MinaRox |
| Database Links | Reactome: R-HSA-3214842Reactome: R-HSA-9629569 |
| Cellular Localisation | NucleusNucleolus |
| Alternative Protein Names | Ribosomal Oxygenase 2 protein60s Ribosomal Protein L27a Histidine Hydroxylase proteinBifunctional Lysine-Specific Demethylase And Histidyl-Hydroxylase Mina proteinHistone Lysine Demethylase Mina proteinMyc-Induced Nuclear Antigen proteinMineral Dust-Induced Gene Protein proteinNucleolar Protein 52 proteinRibosomal Oxygenase Mina proteinRox proteinRIOX2 proteinMDIG proteinMINA proteinMINA53 proteinNO52 protein |
Information sourced from Uniprot.org