Human MINA protein (Recombinant) (His-Tag) (STJP018898)

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STJP018898
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human MINA-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% Glycerol, 1mM DTT
Concentration: 0.25 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: RIOX2
Gene ID: 84864
Uniprot ID: RIOX2_HUMAN
Immunogen Region: 1-465aa
Accession Number: AAH14928
Immunogen: Human
Immunogen Sequence: MPKKAKPTGS GKEEGPAPCK QMKLEAAGGP SALNFDSPSS LFESLISPIK TETFFKEFWE QKPLLIQRDD PALATYYGSL FKLTDLKSLC SRGMYYGRDV NVCRCVNGKK KVLNKDGKAH FLQLRKDFDQ KRATIQFHQP QRFKDELWRI QEKLECYFGS LVGSNVYITP AGSQGLPPHY DDVEVFILQL EGEKHWRLYH PTVPLA
Tissue Specificity Expressed in liver, skeletal muscle, heart, pancreas, and placenta. Not detected in brain, lung or kidney. Expressed in several lung cancer tissues, but is barely detected in the adjacent non-cancerous tissues. Also highly expressed in several esophageal squamous cell carcinoma (ESCC), and colon cancer tissues, and in various cancer cell lines.
Function Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.
Protein Name Ribosomal Oxygenase 2
60s Ribosomal Protein L27a Histidine Hydroxylase
Bifunctional Lysine-Specific Demethylase And Histidyl-Hydroxylase Mina
Histone Lysine Demethylase Mina
Myc-Induced Nuclear Antigen
Mineral Dust-Induced Gene Protein
Nucleolar Protein 52
Ribosomal Oxygenase Mina
Rox
Database Links Reactome: R-HSA-3214842
Reactome: R-HSA-9629569
Cellular Localisation Nucleus
Nucleolus
Alternative Protein Names Ribosomal Oxygenase 2 protein
60s Ribosomal Protein L27a Histidine Hydroxylase protein
Bifunctional Lysine-Specific Demethylase And Histidyl-Hydroxylase Mina protein
Histone Lysine Demethylase Mina protein
Myc-Induced Nuclear Antigen protein
Mineral Dust-Induced Gene Protein protein
Nucleolar Protein 52 protein
Ribosomal Oxygenase Mina protein
Rox protein
RIOX2 protein
MDIG protein
MINA protein
MINA53 protein
NO52 protein

Information sourced from Uniprot.org

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