Human SLPI protein (Recombinant) (His-Tag) (STJP016739)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human SLPI-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol, 2mM DTT, 100mM NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SLPI |
| Gene ID | 6590 |
| Uniprot ID | SLPI_HUMAN |
| Accession Number | NP_003055.1 |
| Immunogen | Human |
| Immunogen Region | 26-132aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Detected in blood plasma. Detected in bone marrow myeloid cells. Detected in airway sputum. Detected in parotid gland secretions. Detected in seminal plasma (at protein level). Detected in uterus cervix. |
| Function | Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. Modulates the inflammatory and immune responses after bacterial infection, and after infection by the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS). Plays a role in regulating the activation of NF-kappa-B and inflammatory responses. Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. Required for normal resistance to infection by L.major. Required for normal wound healing, probably by preventing tissue damage by limiting protease activity. Together with ELANE, required for normal differentiation and proliferation of bone marrow myeloid cells. |
| Protein Name | AntileukoproteinaseAlpBlpiHusi-1Mucus Proteinase InhibitorMpiProtease Inhibitor Wap4Secretory Leukocyte Protease InhibitorSeminal Proteinase InhibitorWap Four-Disulfide Core Domain Protein 4 |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Antileukoproteinase proteinAlp proteinBlpi proteinHusi-1 proteinMucus Proteinase Inhibitor proteinMpi proteinProtease Inhibitor Wap4 proteinSecretory Leukocyte Protease Inhibitor proteinSeminal Proteinase Inhibitor proteinWap Four-Disulfide Core Domain Protein 4 proteinSLPI proteinWAP4 proteinWFDC4 protein |
Information sourced from Uniprot.org