Human MIF protein (Recombinant) (No-Tag) (STJP019704)

Name: Human MIF protein (Recombinant) (No-Tag) (STJP019704)
SKU: STJP019704
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostE.coli

ImmunogenHuman

STJP019704

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Short Description	Recombinant-Human MIF-No-Tag protein was developed from e.coli and has a target region of No-Tag. For use in research applications.
Applications	SDS-PAGE
Host	E.coli
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Concentration	1 mg/mL
Formulation	Liquid in 50mM Tris-HCl buffer (pH 8.0) containing 0.5mM DTT 10% Glycerol
Storage Instruction	For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Endotoxin	< 1 EU per 1ug of protein (determined by LAL method)

Gene Symbol	MIF
Gene ID	4282
Uniprot ID	MIF_HUMAN
Accession Number	NP_002406
Immunogen	Human
Immunogen Region	1-115aa
Immunogen Sequence	MPMFIVNTNV PRASVPDGFL SELTQQLAQA TGKPPQYIAV HVVPDQLMAF GGSSEPCALC SLHSIGKIGG AQNRSYSKLL CGLLAERLRI SPDRVYINYY DMNAANVGWN NSTFA

Function	Pro-inflammatory cytokine involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.
Protein Name	Macrophage Migration Inhibitory Factor Mif Glycosylation-Inhibiting Factor Gif L-Dopachrome Isomerase L-Dopachrome Tautomerase Phenylpyruvate Tautomerase
Database Links	Reactome: R-HSA-202733 Reactome: R-HSA-6798695 Reactome: R-HSA-8950505
Cellular Localisation	Secreted Cytoplasm Does Not Have A Cleavable Signal Sequence And Is Secreted Via A Specialized Non-Classical Pathway Secreted By Macrophages Upon Stimulation By Bacterial Lipopolysaccharide (Lps) Or By M Tuberculosis Antigens
Alternative Protein Names	Macrophage Migration Inhibitory Factor protein Mif protein Glycosylation-Inhibiting Factor protein Gif protein L-Dopachrome Isomerase protein L-Dopachrome Tautomerase protein Phenylpyruvate Tautomerase protein MIF protein GLIF protein MMIF protein

Information sourced from Uniprot.org