Human MICB protein (Recombinant-Active) (C-His) (STJP012128)

Name: Human MICB protein (Recombinant-Active) (C-His) (STJP012128)
SKU: STJP012128-100
Price: 604.2 EUR
Availability: InStock

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SPECIFICATIONS

HostMammalian Cells

ConjugationUnconjugated

ImmunogenHomo sapiens (Human)

STJP012128-100

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Short Description	Recombinant-Active-Human MICB-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Applications	ELISA/WB
Host	Mammalian Cells
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Conjugation	Unconjugated
Dilution Range	Reconstitute in sterile water for a stock solution.
Formulation	Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Storage Instruction	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin	<0.1 EU/Mu g of the protein by the LAL method.
Immunoreactivity	Measured by its binding ability in a functional ELISA. When recombinant human NKG2D/CD314 Fc Chimera is Immobilised at 0.125 Mu g/mL, 100 Mu L/well, the concentration of recombinant human MICB that produces 50% of the optimal binding response is appr

Post Translational Modifications	Proteolytically cleaved and released from the cell surface of tumor cells.
Function	Widely expressed membrane-bound protein which acts as a ligand to stimulate an activating receptor KLRK1/NKG2D, expressed on the surface of essentially all human natural killer (NK), gammadelta T and CD8+ alphabeta T-cells. Up-regulated in stressed conditions, such as viral and bacterial infections or DNA damage response, serves as signal of cellular stress, and engagement of KLRK1/NKG2D by MICA triggers NK-cells resulting in a range of immune effector functions, such as cytotoxicity and cytokine production.
Protein Name	Mhc Class I Polypeptide-Related Sequence B Mic-B
Database Links	Reactome: R-HSA-198933
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Binding To Human Cytomegalovirus Glycoprotein Ul16 Causes Sequestration In The Endoplasmic Reticulum
Alternative Protein Names	Mhc Class I Polypeptide-Related Sequence B protein Mic-B protein MICB protein PERB11.2 protein

Information sourced from Uniprot.org