Human MIB1 protein (Recombinant) (N-His) (STJP005665)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human MIB1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | MIB1 |
| Gene ID | 57534 |
| Uniprot ID | MIB1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Arg769-Glu1000 |
Additional Info
| Post Translational Modifications | Ubiquitinated.possibly via autoubiquitination. Ubiquitinated.this modification is inhibited in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock. |
| Function | E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis. Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation. (Microbial infection) During adenovirus infection, mediates ubiquitination of Core-capsid bridging protein. This allows viral genome delivery into nucleus for infection. |
| Protein Name | E3 Ubiquitin-Protein Ligase Mib1Dapk-Interacting Protein 1Dip-1Mind Bomb Homolog 1Ring-Type E3 Ubiquitin Transferase Mib1Zinc Finger Zz Type With Ankyrin Repeat Domain Protein 2 |
| Database Links | Reactome: R-HSA-2122948Reactome: R-HSA-2644606Reactome: R-HSA-2691232Reactome: R-HSA-2894862Reactome: R-HSA-2979096Reactome: R-HSA-9013507 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCentriolar SatelliteCell MembraneLocalizes To The Plasma MembraneIt Is MitochondrialHowever Such Localization Remains UnclearDisplaced From Centriolar Satellites In Response To Cellular StressSuch As Ultraviolet Light (Uv) Radiation Or Heat Shock |
| Alternative Protein Names | E3 Ubiquitin-Protein Ligase Mib1 proteinDapk-Interacting Protein 1 proteinDip-1 proteinMind Bomb Homolog 1 proteinRing-Type E3 Ubiquitin Transferase Mib1 proteinZinc Finger Zz Type With Ankyrin Repeat Domain Protein 2 proteinMIB1 proteinDIP1 proteinKIAA1323 proteinZZANK2 protein |
Information sourced from Uniprot.org