| Post Translational Modifications | Cleaved by CASP1 (Probable). The N-terminal cleavage product localizes to the nucleus as a filamentous network and to the cytoplasm, interacts more strongly with RELA and NFKBIA than the full-length protein, enhances the nuclear localization of RELA and induces NFKBIA proteolysis. The C-terminal cleavage product localizes to the cytoplasm (Probable). Phosphorylation at Ser-242 is required for the interaction with 14-3-3 proteins and down-regulation of pyrin pro-inflammatory activity. Degraded along with the delivery of its substrates to autolysosomal compartments (at protein level). |
| Function | Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation. However, it can also have a positive effect in the inflammatory pathway, acting as an innate immune sensor that triggers PYCARD/ASC specks formation, caspase-1 activation, and IL1B and IL18 production. Together with AIM2, also acts as a mediator of pyroptosis, necroptosis and apoptosis (PANoptosis), an integral part of host defense against pathogens, in response to bacterial infection. It is required for PSTPIP1-induced PYCARD/ASC oligomerization and inflammasome formation. Recruits PSTPIP1 to inflammasomes, and is required for PSTPIP1 oligomerization. |
| Protein Name | PyrinMarenostrin |
| Database Links | Reactome: R-HSA-844456Reactome: R-HSA-9660826 |
| Cellular Localisation | Isoform 1: CytoplasmCytoskeletonCell ProjectionRuffleLamellipodiumNucleusCytoplasmCytoplasmic VesicleAutophagosomeAssociated With Microtubules And With The Filamentous Actin Of Perinuclear Filaments And Peripheral Lamellar RufflesIn Pre-Apoptotic CellsColocalizes With Pycard/Asc In Large Specks (Inflammasomes)In Migrating MonocytesStrongly Polarized At The Leading Edge Of The Cell Where It Colocalizes With Polymerizing Actin And Pycard/AscIsoform 2: Nucleus |
| Alternative Protein Names | Pyrin proteinMarenostrin proteinMEFV proteinMEF proteinTRIM20 protein |
Information sourced from Uniprot.org
