Human MED15 protein (Recombinant) (N-His-SUMO & C-Strep) (STJP007433)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human MED15-N-His-SUMO & C-Strep protein was developed from e.coli for the region N-His-SUMO & C-Strep. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | MED15 |
| Gene ID | 51586 |
| Uniprot ID | MED15_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser676-Ala788 |
Additional Info
| Post Translational Modifications | Ubiquitinated by TRIM11, leading to proteasomal degradation. |
| Function | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation. Positively regulates the Nodal signaling pathway. |
| Protein Name | Mediator Of Rna Polymerase Ii Transcription Subunit 15Activator-Recruited Cofactor 105 Kda ComponentArc105Ctg Repeat Protein 7aMediator Complex Subunit 15Positive Cofactor 2 Glutamine/Q-Rich-Associated ProteinPc2 Glutamine/Q-Rich-Associated ProteinTpa-Inducible Gene 1 ProteinTig-1Trinucleotide Repeat-Containing Gene 7 Protein |
| Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-212436Reactome: R-HSA-381340Reactome: R-HSA-9833110 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Protein Names | Mediator Of Rna Polymerase Ii Transcription Subunit 15 proteinActivator-Recruited Cofactor 105 Kda Component proteinArc105 proteinCtg Repeat Protein 7a proteinMediator Complex Subunit 15 proteinPositive Cofactor 2 Glutamine/Q-Rich-Associated Protein proteinPc2 Glutamine/Q-Rich-Associated Protein proteinTpa-Inducible Gene 1 Protein proteinTig-1 proteinTrinucleotide Repeat-Containing Gene 7 Protein proteinMED15 proteinARC105 proteinCTG7A proteinPCQAP proteinTIG1 proteinTNRC7 protein |
Information sourced from Uniprot.org