• Biotinylated Human MCP-1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
  • The purity of Biotinylated Human MCP-1 is greater than 95% as determined by SEC-HPLC.

Human MCP-1/CCL2 protein (Recombinant) (C-His-Avi) {Biotin} (STJP001547)

SKU:
STJP001547

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Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human MCP-1/CCL2-C-His-Avi protein was developed from hek293 and has a target region of C-His-Avi. For use in research applications.
Conjugation: Biotin
Formulation: Lyophilised from 0.2 µm filtered PBS solution pH7.4.
Dilution Range: Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM
Storage Instruction: The lyophilized protein is stable for at least 1 year from date of receipt at-20°C.
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).
Gene Symbol: CCL2
Gene ID: 6347
Uniprot ID: CCL2_HUMAN
Immunogen Region: Gln24-Thr99
Immunogen: DNA sequence encoding Human MCP-1/CCL2 including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.
Post Translational Modifications Processing at the N-terminus can regulate receptor and target cell selectivity. Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant. N-Glycosylated.
Function Acts as a ligand for C-C chemokine receptor CCR2. Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions. Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.
Protein Name C-C Motif Chemokine 2
Hc11
Monocyte Chemoattractant Protein 1
Monocyte Chemotactic And Activating Factor
Mcaf
Monocyte Chemotactic Protein 1
Mcp-1
Monocyte Secretory Protein Je
Small-Inducible Cytokine A2
Database Links Reactome: R-HSA-380108
Reactome: R-HSA-380994
Reactome: R-HSA-6783783
Reactome: R-HSA-6785807
Cellular Localisation Secreted
Alternative Protein Names C-C Motif Chemokine 2 protein
Hc11 protein
Monocyte Chemoattractant Protein 1 protein
Monocyte Chemotactic And Activating Factor protein
Mcaf protein
Monocyte Chemotactic Protein 1 protein
Mcp-1 protein
Monocyte Secretory Protein Je protein
Small-Inducible Cytokine A2 protein
CCL2 protein
MCP1 protein
SCYA2 protein

Information sourced from Uniprot.org

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