| Function | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division (Probable). |
| Protein Name | Dna Replication Licensing Factor Mcm3Dna Polymerase Alpha Holoenzyme-Associated Protein P1P1-Mcm3Rlf Subunit BetaP102 |
| Database Links | Reactome: R-HSA-176187Reactome: R-HSA-176974Reactome: R-HSA-68867Reactome: R-HSA-68949Reactome: R-HSA-68962Reactome: R-HSA-69052 |
| Cellular Localisation | NucleusChromosomeAssociated With Chromatin Before The Formation Of Nuclei And Detaches From It As Dna Replication Progresses |
| Alternative Protein Names | Dna Replication Licensing Factor Mcm3 proteinDna Polymerase Alpha Holoenzyme-Associated Protein P1 proteinP1-Mcm3 proteinRlf Subunit Beta proteinP102 proteinMCM3 protein |
Information sourced from Uniprot.org
