| Short Description : | Recombinant-Human MBP-C/MBL-2-C-His protein was developed in hek293 cells using the region Glu21-Ile248. For use in research applications. |
| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: | MBL2 |
| Gene ID: | 4153 |
| Uniprot ID: | MBL2_HUMAN |
| Immunogen: | Recombinant Human MBP-C/MBL-2 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Glu21-Ile248) of human MBL2/MBL/COLEC1 (Accession #NP_000233.1) fused with a 6×His tag at the C-terminus. |
| Immunogen Region: | Glu21-Ile248 |
| Immunogen Sequence: | ETVTCEDAQKTCPAVIACSS PGINGFPGKDGRDGTKGEKG EPGQGLRGLQGPPGKLGPPG NPGPSGSPGPKGQKGDPGKS PDGDSSLAASERKALQTEMA RIKKWLTFSLGKQVGNKFFL TNGEIMTFEKVKALCVKFQA SVATPRNAAENGAIQNLIKE EAFLGITDEKTEGQFVDLTG NRLTYTNWNEGEPNNAGSDE DCVLLLKNGQWNDVPCSTSH LAVCEFPI |
| Tissue Specificity | Plasma protein produced mainly in the liver. |
| Function | Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA. Upon SARS coronavirus-2/SARS-CoV-2 infection, activates the complement lectin pathway which leads to the inhibition SARS-CoV-2 infection and a reduction of the induced inflammatory response. |
| Protein Name | Mannose-Binding Protein CMbp-CCollectin-1Mbp1Mannan-Binding ProteinMannose-Binding Lectin |
| Database Links | Reactome: R-HSA-166662Reactome: R-HSA-166663Reactome: R-HSA-9705671 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Mannose-Binding Protein C proteinMbp-C proteinCollectin-1 proteinMbp1 proteinMannan-Binding Protein proteinMannose-Binding Lectin proteinMBL2 proteinCOLEC1 proteinMBL protein |
Information sourced from Uniprot.org
