Human MBL2 protein (Recombinant) (N-His) (STJP003995)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human MBL2-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | MBL2 |
| Gene ID | 4153 |
| Uniprot ID | MBL2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Glu21-Ile248 |
Additional Info
| Function | Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA. Upon SARS coronavirus-2/SARS-CoV-2 infection, activates the complement lectin pathway which leads to the inhibition SARS-CoV-2 infection and a reduction of the induced inflammatory response. |
| Protein Name | Mannose-Binding Protein CMbp-CCollectin-1Mbp1Mannan-Binding ProteinMannose-Binding Lectin |
| Database Links | Reactome: R-HSA-166662Reactome: R-HSA-166663Reactome: R-HSA-9705671 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Mannose-Binding Protein C proteinMbp-C proteinCollectin-1 proteinMbp1 proteinMannan-Binding Protein proteinMannose-Binding Lectin proteinMBL2 proteinCOLEC1 proteinMBL protein |
Information sourced from Uniprot.org