Human Mature BMP-10 protein (Recombinant) (NO-Tag) (STJP020063)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human Mature BMP-10 Protein is produced by HEK293 cells system. The target protein is expressed with sequence (Ser22-Arg424) of Human Mature BMP-10 (Accession #NP_055297.1) fused with No Tag.
General Information
| Short Description | Recombinant-Human Mature BMP-10-NO-Tag protein was developed in hek293 cells using the region Ser22-Arg424. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from 0.22 Mu m filtered solution in 4mM HCl. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | BMP10 |
| Gene ID | 27302 |
| Uniprot ID | BMP10_HUMAN |
| Immunogen | Recombinant Human Mature BMP-10 Protein is produced by HEK293 cells system. The target protein is expressed with sequence (Ser22-Arg424) of Human Mature BMP-10 (Accession #NP_055297.1) fused with No Tag. |
| Immunogen Region | Ser22-Arg424 |
| Immunogen Sequence | SPIMNLEQSPLEEDMSLFGD VFSEQDGVDFNTLLQSMKDE FLKTLNLSDIPTQDSAKVDP PEYMLELYNKFATDRTSMPS ANIIRSFKNEDLFSQPVSFN GLRKYPLLFNVSIPHHEEVI MAELRLYTLVQRDRMIYDGV DRKITIFEVLESKGDNEGER NMLVLVSGEIYGTNSEWETF DVTDAIRRWQKSGSSTHQLE VHIESKHDEAEDASSGRLEI DTSAQNKHNPLLIVFSDDQ |
Additional Info
| Tissue Specificity | Detected in mammary epithelia (at protein level). |
| Function | Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines. |
| Protein Name | Bone Morphogenetic Protein 10Bmp-10 |
| Database Links | Reactome: R-HSA-201451Reactome: R-HSA-2129379 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Bone Morphogenetic Protein 10 proteinBmp-10 proteinBMP10 protein |
Information sourced from Uniprot.org