Human MASP2 protein (Recombinant) (N-His) (STJP003130)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human MASP2-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | MASP2 |
| Gene ID | 10747 |
| Uniprot ID | MASP2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Thr287-Phe686 |
Additional Info
| Post Translational Modifications | The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. Activated by cleavage after Arg-444. The uncleaved zymogen is inactive towards synthetic substrates, but has sufficient activity to effect autocatalytic cleavage. |
| Function | Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase. |
| Protein Name | Mannan-Binding Lectin Serine Protease 2Mbl-Associated Serine Protease 2Mannose-Binding Protein-Associated Serine Protease 2Masp-2 Cleaved Into - Mannan-Binding Lectin Serine Protease 2 A Chain - Mannan-Binding Lectin Serine Protease 2 B Chain |
| Database Links | Reactome: R-HSA-166662 O00187-1Reactome: R-HSA-166663 O00187-1Reactome: R-HSA-2855086 O00187-1Reactome: R-HSA-9705671 O00187-1 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Mannan-Binding Lectin Serine Protease 2 proteinMbl-Associated Serine Protease 2 proteinMannose-Binding Protein-Associated Serine Protease 2 proteinMasp-2 Cleaved Into - Mannan-Binding Lectin Serine Protease 2 A Chain - Mannan-Binding Lectin Serine Protease 2 B Chain proteinMASP2 protein |
Information sourced from Uniprot.org