Human MAPRE3 protein (Recombinant) (His-Tag) (STJP016886)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human MAPRE3-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol, 2mM DTT, 0.1M NaCl. |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MAPRE3 |
| Gene ID | 22924 |
| Uniprot ID | MARE3_HUMAN |
| Accession Number | NP_036458 |
| Immunogen | Human |
| Immunogen Region | 1-281aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Predominantly expressed in brain and muscle. |
| Function | Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules. |
| Protein Name | Microtubule-Associated Protein Rp/Eb Family Member 3Eb1 Protein Family Member 3Ebf3End-Binding Protein 3Eb3Rp3 |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonAssociated With The Microtubule NetworkDetected At The Plus End Of Microtubules |
| Alternative Protein Names | Microtubule-Associated Protein Rp/Eb Family Member 3 proteinEb1 Protein Family Member 3 proteinEbf3 proteinEnd-Binding Protein 3 proteinEb3 proteinRp3 proteinMAPRE3 protein |
Information sourced from Uniprot.org