Human MAPRE2 protein (Recombinant) (His-Tag) (STJP017340)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human MAPRE2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol, 0.1M NaCl, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MAPRE2 |
| Gene ID | 10982 |
| Uniprot ID | MARE2_HUMAN |
| Accession Number | NP_055083.1 |
| Immunogen | Human |
| Immunogen Region | 1-327aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Expressed in different tumor cell lines. Up-regulated in activated B- and T-lymphocytes. |
| Post Translational Modifications | Phosphorylated at Ser-236 by CK2 leading to enhanced cell adhesion. Phosphorylated by CDK1 and AURKB during mitosis reduces the binding affinity of MAPRE2 for microtubules. Ubiquitinated in an ASB14-dependent manner.leading to proteasomal degradation. |
| Function | Adapter protein that is involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. Therefore, ensures mitotic progression and genome stability. Acts as a central regulator of microtubule reorganization in apico-basal epithelial differentiation. Plays a role during oocyte meiosis by regulating microtubule dynamics. Participates in neurite growth by interacting with plexin B3/PLXNB3 and microtubule reorganization during apico-basal epithelial differentiation. Also plays an essential role for cell migration and focal adhesion dynamics. Mechanistically, recruits HAX1 to microtubules in order to regulate focal adhesion dynamics. |
| Protein Name | Microtubule-Associated Protein Rp/Eb Family Member 2Apc-Binding Protein Eb2End-Binding Protein 2Eb2 |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonAssociated With The Microtubule NetworkAccumulates At The Plus End Of Microtubules |
| Alternative Protein Names | Microtubule-Associated Protein Rp/Eb Family Member 2 proteinApc-Binding Protein Eb2 proteinEnd-Binding Protein 2 proteinEb2 proteinMAPRE2 proteinRP1 protein |
Information sourced from Uniprot.org