Human MAPK7 protein (Recombinant) (N-GST) (STJP005296)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human MAPK7-N-GST protein was developed from e.coli for the region N-GST. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | MAPK7 |
| Gene ID | 5598 |
| Uniprot ID | MK07_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Val560-Glu793 |
Additional Info
| Post Translational Modifications | Dually phosphorylated on Thr-219 and Tyr-221, which activates the enzyme. Autophosphorylated in vitro on threonine and tyrosine residues when the C-terminal part of the kinase, which could have a regulatory role, is absent. |
| Function | Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via interaction with STUB1/CHIP and promotion of STUB1-mediated ubiquitination and degradation of ICER-type isoforms of CREM. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction. |
| Protein Name | Mitogen-Activated Protein Kinase 7Map Kinase 7Mapk 7Big Map Kinase 1Bmk-1Extracellular Signal-Regulated Kinase 5Erk-5 |
| Database Links | Reactome: R-HSA-198753Reactome: R-HSA-198765Reactome: R-HSA-202670Reactome: R-HSA-2559582Reactome: R-HSA-881907Reactome: R-HSA-8853659 |
| Cellular Localisation | CytoplasmNucleusPml BodyTranslocates To The Nucleus Upon Activation |
| Alternative Protein Names | Mitogen-Activated Protein Kinase 7 proteinMap Kinase 7 proteinMapk 7 proteinBig Map Kinase 1 proteinBmk-1 proteinExtracellular Signal-Regulated Kinase 5 proteinErk-5 proteinMAPK7 proteinBMK1 proteinERK5 proteinPRKM7 protein |
Information sourced from Uniprot.org