Human MAPK4 protein (Recombinant) (N-His) (STJP007966)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human MAPK4-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | MAPK4 |
| Gene ID | 5596 |
| Uniprot ID | MK04_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Ser313 |
Additional Info
| Post Translational Modifications | Phosphorylated at Ser-186 by PAK1, PAK2 and PAK3 resulting in catalytic activation. Phosphorylated by MAPKAPK5 at other sites. |
| Function | Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle. |
| Protein Name | Mitogen-Activated Protein Kinase 4Map Kinase 4Mapk 4Extracellular Signal-Regulated Kinase 4Erk-4Map Kinase Isoform P63P63-Mapk |
| Database Links | Reactome: R-HSA-5687128 |
| Cellular Localisation | CytoplasmNucleusTranslocates To The Cytoplasm Following Interaction With Mapkapk5 |
| Alternative Protein Names | Mitogen-Activated Protein Kinase 4 proteinMap Kinase 4 proteinMapk 4 proteinExtracellular Signal-Regulated Kinase 4 proteinErk-4 proteinMap Kinase Isoform P63 proteinP63-Mapk proteinMAPK4 proteinERK4 proteinPRKM4 protein |
Information sourced from Uniprot.org