Human MAP2K2 protein (Recombinant-Active) (N-GST) (STJP011977)
SPECIFICATIONS
HostInsect Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Active-Human MAP2K2-N-GST protein was developed from insect cells and has a target region of N-GST. For use in research applications. |
| Applications | ELISA/WB |
| Host | Insect Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity | The specific activity of MAP2K2/MEK2 was determined to be 190 nmol/min/mg as per activity assay protocol. |
Target Information
| Gene Symbol | MAP2K2 |
| Gene ID | 5605 |
| Uniprot ID | MP2K2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Val400 |
Additional Info
| Function | Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases. Activates BRAF in a KSR1 or KSR2-dependent manner.by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation. |
| Protein Name | Dual Specificity Mitogen-Activated Protein Kinase Kinase 2Map Kinase Kinase 2Mapkk 2Erk Activator Kinase 2Mapk/Erk Kinase 2Mek 2 |
| Database Links | Reactome: R-HSA-112411Reactome: R-HSA-170968Reactome: R-HSA-445144Reactome: R-HSA-5210891Reactome: R-HSA-5673000Reactome: R-HSA-5674135Reactome: R-HSA-5674499Reactome: R-HSA-6802946Reactome: R-HSA-6802948Reactome: R-HSA-6802952Reactome: R-HSA-6802955Reactome: R-HSA-9649948Reactome: R-HSA-9652169Reactome: R-HSA-9656223 |
| Cellular Localisation | CytoplasmMembranePeripheral Membrane ProteinMembrane Localization Is Probably Regulated By Its Interaction With Ksr1 |
| Alternative Protein Names | Dual Specificity Mitogen-Activated Protein Kinase Kinase 2 proteinMap Kinase Kinase 2 proteinMapkk 2 proteinErk Activator Kinase 2 proteinMapk/Erk Kinase 2 proteinMek 2 proteinMAP2K2 proteinMEK2 proteinMKK2 proteinPRKMK2 protein |
Information sourced from Uniprot.org