Human MAP1B protein (Recombinant) (N-His) (STJP004769)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human MAP1B-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | MAP1B |
| Gene ID | 4131 |
| Uniprot ID | MAP1B_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Lys414-Glu567 |
Additional Info
| Function | Facilitates tyrosination of alpha-tubulin in neuronal microtubules. Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension. Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. |
| Protein Name | Microtubule-Associated Protein 1bMap-1b Cleaved Into - Map1b Heavy Chain - Map1 Light Chain Lc1 |
| Database Links | Reactome: R-HSA-9833110 |
| Cellular Localisation | CytoplasmCytoskeletonSynapseCell ProjectionDendritic SpineColocalizes With Dapk1 In The Microtubules And Cortical Actin FibersMap1 Light Chain Lc1: Cytoplasm |
| Alternative Protein Names | Microtubule-Associated Protein 1b proteinMap-1b Cleaved Into - Map1b Heavy Chain - Map1 Light Chain Lc1 proteinMAP1B protein |
Information sourced from Uniprot.org