Human MAP1/MOAP1 protein (Recombinant) (His-Tag) (STJP018505)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human MAP1/MOAP1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Denatured |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol 0.4M urea |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MOAP1 |
| Gene ID | 64112 |
| Uniprot ID | MOAP1_HUMAN |
| Accession Number | NP_071434 |
| Immunogen | Human |
| Immunogen Region | 1-351aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSMTLRLLE DWCRGMDMNP RKALLIAGIS QSCSVAEIEE ALQAGLAPLG EYRLLGRMFR RDENRKVALV GLTAETSHAL VPKEIPGKGG IWRVIFKPPD PDNTFLSRLN EFLAGEGMTV GELSRALGHE NGSLDPEQGM IPEMWAPMLA QALEALQPAL QCLKYKKLRV FSGRESPEPG EEEFGRWMFH TTQMIKAWQV PDVEKRRR |
Additional Info
| Tissue Specificity | Widely expressed, with high levels in heart and brain. |
| Post Translational Modifications | Ubiquitinated and degraded during mitotic exit by APC/C-Cdh1, this modification is inhibited by TRIM39. |
| Function | Retrotransposon-derived protein that forms virion-like capsids. Acts as an effector of BAX during apoptosis: enriched at outer mitochondria membrane and associates with BAX upon induction of apoptosis, facilitating BAX-dependent mitochondrial outer membrane permeabilization and apoptosis. Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Also promotes autophagy: promotes phagophore closure via association with ATG8 proteins. Acts as an inhibitor of the NFE2L2/NRF2 pathway via interaction with SQSTM1: interaction promotes dissociation of SQSTM1 inclusion bodies that sequester KEAP1, relieving inactivation of the BCR(KEAP1) complex. |
| Protein Name | Modulator Of Apoptosis 1Map-1Map1Paraneoplastic Antigen Ma4 |
| Database Links | |
| Cellular Localisation | CytoplasmCytosolMitochondrion Outer MembraneExtracellular Vesicle MembraneForms Virion-Like Extracellular Vesicles That Are Released From Cells |
| Alternative Protein Names | Modulator Of Apoptosis 1 proteinMap-1 proteinMap1 proteinParaneoplastic Antigen Ma4 proteinMOAP1 proteinPNMA4 protein |
Information sourced from Uniprot.org