| Tissue Specificity | Widely expressed, with high levels in heart and brain. |
| Post Translational Modifications | Ubiquitinated and degraded during mitotic exit by APC/C-Cdh1, this modification is inhibited by TRIM39. |
| Function | Retrotransposon-derived protein that forms virion-like capsids. Acts as an effector of BAX during apoptosis: enriched at outer mitochondria membrane and associates with BAX upon induction of apoptosis, facilitating BAX-dependent mitochondrial outer membrane permeabilization and apoptosis. Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Also promotes autophagy: promotes phagophore closure via association with ATG8 proteins. Acts as an inhibitor of the NFE2L2/NRF2 pathway via interaction with SQSTM1: interaction promotes dissociation of SQSTM1 inclusion bodies that sequester KEAP1, relieving inactivation of the BCR(KEAP1) complex. |
| Protein Name | Modulator Of Apoptosis 1Map-1Map1Paraneoplastic Antigen Ma4 |
| Database Links | |
| Cellular Localisation | CytoplasmCytosolMitochondrion Outer MembraneExtracellular Vesicle MembraneForms Virion-Like Extracellular Vesicles That Are Released From Cells |
| Alternative Protein Names | Modulator Of Apoptosis 1 proteinMap-1 proteinMap1 proteinParaneoplastic Antigen Ma4 proteinMOAP1 proteinPNMA4 protein |
Information sourced from Uniprot.org
