Human mannan-binding lectin/MBL2 protein (Recombinant) (His-Tag) (STJP017920)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human mannan-binding lectin/MBL2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Denatured |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 2M urea, 20% Glycerol, 0.2M Nacl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MBL2 |
| Gene ID | 4153 |
| Uniprot ID | MBL2_HUMAN |
| Accession Number | NP_000233 |
| Immunogen | Human |
| Immunogen Region | 108-248aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSAASERKA LQTEMARIKK WLTFSLGKQV GNKFFLTNGE IMTFEKVKAL CVKFQASVAT PRNAAENGAI QNLIKEEAFL GITDEKTEGQ FVDLTGNRLT YTNWNEGEPN NAGSDEDCVL LLKNGQWNDV PCSTSHLAVC EFPI |
Additional Info
| Tissue Specificity | Plasma protein produced mainly in the liver. |
| Function | Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA. Upon SARS coronavirus-2/SARS-CoV-2 infection, activates the complement lectin pathway which leads to the inhibition SARS-CoV-2 infection and a reduction of the induced inflammatory response. |
| Protein Name | Mannose-Binding Protein CMbp-CCollectin-1Mbp1Mannan-Binding ProteinMannose-Binding Lectin |
| Database Links | Reactome: R-HSA-166662Reactome: R-HSA-166663Reactome: R-HSA-9705671 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Mannose-Binding Protein C proteinMbp-C proteinCollectin-1 proteinMbp1 proteinMannan-Binding Protein proteinMannose-Binding Lectin proteinMBL2 proteinCOLEC1 proteinMBL protein |
Information sourced from Uniprot.org