Human MAGED1 protein (Recombinant) (N-His) (STJP007864)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human MAGED1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | MAGED1 |
| Gene ID | 9500 |
| Uniprot ID | MAGD1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Arg466-Arg745 |
Additional Info
| Function | Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as BMAL1 and NFIL3, induced, or NR1D1, repressed. |
| Protein Name | Melanoma-Associated Antigen D1Mage Tumor Antigen CcfMage-D1 AntigenNeurotrophin Receptor-Interacting Mage Homolog |
| Database Links | Reactome: R-HSA-193648Reactome: R-HSA-418889Reactome: R-HSA-9768919 |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane ProteinNucleusExpression Shifts From The Cytoplasm To The Plasma Membrane Upon Stimulation With Ngf |
| Alternative Protein Names | Melanoma-Associated Antigen D1 proteinMage Tumor Antigen Ccf proteinMage-D1 Antigen proteinNeurotrophin Receptor-Interacting Mage Homolog proteinMAGED1 proteinNRAGE proteinPP2250 proteinPRO2292 protein |
Information sourced from Uniprot.org