Human M-CSF protein (Recombinant) (His-Tag) (STJP016574)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human M-CSF-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) 2mM DTT, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Endotoxin | < 1 EU per 1ug of protein (determined by LAL method) |
Target Information
| Gene Symbol | CSF1 |
| Gene ID | 1435 |
| Uniprot ID | CSF1_HUMAN |
| Accession Number | NP_757351.2 |
| Immunogen | Human |
| Immunogen Region | 33-190aa |
| Immunogen Sequence |
Additional Info
| Post Translational Modifications | N-glycosylated. Isoform 1: N-glycosylated. Isoform 3: N-glycosylated. O-glycosylated.contains chondroitin sulfate. O-glycosylated with core 1 or possibly core 8 glycans. Isoform 1: O-glycosylated. |
| Function | Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance. |
| Protein Name | Macrophage Colony-Stimulating Factor 1Csf-1M-CsfMcsfLanimostimProteoglycan Macrophage Colony-Stimulating FactorPg-M-Csf Cleaved Into - Processed Macrophage Colony-Stimulating Factor 1 - Macrophage Colony-Stimulating Factor 1 43 Kda Subunit |
| Database Links | Reactome: R-HSA-381426Reactome: R-HSA-449836Reactome: R-HSA-6783783Reactome: R-HSA-8957275Reactome: R-HSA-9680350Reactome: R-HSA-9856649 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinProcessed Macrophage Colony-Stimulating Factor 1: SecretedExtracellular Space |
| Alternative Protein Names | Macrophage Colony-Stimulating Factor 1 proteinCsf-1 proteinM-Csf proteinMcsf proteinLanimostim proteinProteoglycan Macrophage Colony-Stimulating Factor proteinPg-M-Csf Cleaved Into - Processed Macrophage Colony-Stimulating Factor 1 - Macrophage Colony-Stimulating Factor 1 43 Kda Subunit proteinCSF1 protein |
Information sourced from Uniprot.org